Huiyou Xu, Yatie Qiu, Jingxin Chen, Yan Shi, Xiaoqin Zhang, Qiang Song, Mingqing Huang, Zujian Wu* and Lin Ni*. Chemical constituents and their activities from the seeds of Ormosia hosiei. [J] Natural Product Communication

  发布时间: 2019-07-10   信息员:   


A new cytisine-like alkaloid, hosimonoal (1), with a fused monoterpene group, and 6 known compounds (2-6) were isolated from the seeds of Ormosia hosiei Hemsl. et Wils. The structure of the new compound was confirmed by high resolution electrospray ionization mass spectroscopy (HRESIMS), 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, and electronic circular dichroism, and the others by 1H and 13C NMR spectroscopy and comparison with the literature data. In addition, compounds 1, 2, 3, and 6showed moderate cytotoxic effects against A2780, A-549, HepG2, and MCF-7 cell lines with IC50 values ranging from 5.7 to 36.5 μM.

Keywords: Ormosia hosieihosimonoalcytisine-likealkaloidcytotoxic


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